2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid
2,6-Dichloro-5-fluoronicotinic acid
CAS: 82671-06-5
Molecular Formula: C6H2Cl2FNO2
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid - Names and Identifiers
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid - Physico-chemical Properties
| Molecular Formula | C6H2Cl2FNO2 |
| Molar Mass | 209.99 |
| Density | 1.6207 (estimate) |
| Melting Point | 152-155 °C (lit.) |
| Boling Point | 247°C (rough estimate) |
| Flash Point | 102.1°C |
| Vapor Presure | 0.029mmHg at 25°C |
| Appearance | Crystalline powder |
| Color | White to Yellow to Orange |
| BRN | 4311035 |
| pKa | 1.38±0.32(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Refractive Index | 1.531 |
| MDL | MFCD00799517 |
| Use | Used as a pharmaceutical Intermediate |
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 1 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid - Reference Information
| Application | 2, 6-dichloro-5-fluoronicotinic acid, 6-dichloro-5-fluoro-3-carboxylic acid pyridine, is an important intermediate for the synthesis of the third generation of quinolone drugs, is the preparation of fluorine-containing naphthyridine ring antibacterial drugs (such, cyprofluroxic acid, picrofluoridic acid, polyfluoridic acid) intermediates, these drugs are currently less than the application of ciprofloxacin in China. |
| preparation | 2, 6-dichloro-5-fluoro-3-cyano pyridine, A certain proportion of ammonium sulfate is put into the reaction system, the reaction is for a certain time, cooling, adding a hydrolysis accelerator, heating up, reacting for a period of time, and after post-treatment, a beige to light brown sand product can be obtained, that is, 2,6-two chlorine 5 A fluorine nicotinic acid. |
| synthesis procedure | synthesis procedure 1. The synthesis reaction equation of ethyl fluoroacetate is: the synthesis reaction equation of 2, 6-dihydroxy-5-fluoro-3-cyanopyridine is: 2, the reaction equation for the synthesis of 6-dichloro-5-fluoro-3-cyanopyridine is: 2, the reaction equation for the synthesis of 6-dichloro-5-fluoronicotinic acid is |
| Use | for pharmaceutical intermediates |
Last Update：2024-04-09 15:16:53
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